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Circulating fibrosis biomarkers and risk of atrial fibrillation: The Cardiovascular Health Study (CHS).
Monday,2014-05-05 13:14 America/Los_Angeles — poolea2
| Title | Circulating fibrosis biomarkers and risk of atrial fibrillation: The Cardiovascular Health Study (CHS). |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Rosenberg, MA, Maziarz, M, Tan, AY, Glazer, NL, Zieman, SJ, Kizer, JR, Ix, JH, Djoussé, L, Siscovick, DS, Heckbert, SR, Mukamal, KJ |
| Journal | Am Heart J |
| Volume | 167 |
| Issue | 5 |
| Pagination | 723-8.e2 |
| Date Published | 2014 May |
| ISSN | 1097-6744 |
| Keywords | Aged, Atrial Fibrillation, Biomarkers, Cardiomyopathies, Electrocardiography, Enzyme-Linked Immunosorbent Assay, Female, Fibrosis, Follow-Up Studies, Humans, Incidence, Male, Peptide Fragments, Procollagen, Prospective Studies, Risk Factors, Time Factors, Transforming Growth Factor beta1, United States |
| Abstract | <p><b>BACKGROUND: </b>Cardiac fibrosis is thought to play a central role in the pathogenesis of atrial fibrillation (AF). Retrospective studies have suggested that circulating fibrosis biomarkers are associated with AF, but prospective studies are limited.</p><p><b>METHODS: </b>We measured circulating levels of 2 fibrosis biomarkers, procollagen type III, N-terminal propeptide (PIIINP) and transforming growth factor β1 among participants of the CHS, a population-based study of older Americans. We used Cox proportional hazards and competing risks models to examine adjusted risk of incident AF over a median follow-up of 8.8 years.</p><p><b>RESULTS: </b>Levels of PIIINP were assessed in 2,935 participants, of whom 767 developed AF. Compared with the median PIIINP level (4.45 μg/L), adjusted hazard ratios (95% CIs) were 0.85 (0.72-1.00) at the 10th percentile, 0.93 (0.88-0.99) at the 25th percentile, 1.04 (0.95-1.04) at the 75th percentile, and 1.07 (0.90-1.26) at the 90th. Transforming growth factor β1 levels, assessed in 1,538 participants with 408 cases of incident AF, were not associated with AF risk.</p><p><b>CONCLUSION: </b>In older adults, PIIINP levels were associated with risk of incident AF in a complex manner, with an association that appeared to be positive up to median levels but with little relationship beyond that. Further studies are required to confirm and possibly delineate the mechanism for this relationship.</p> |
| DOI | 10.1016/j.ahj.2014.01.010 |
| Alternate Journal | Am. Heart J. |
| PubMed ID | 24766983 |
| PubMed Central ID | PMC4060155 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |