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Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study.
Friday,2014-02-28 14:27 America/Los_Angeles — poolea2
| Title | Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Whitson, HE, Arnold, AM, Yee, LM, Mukamal, KJ, Kizer, JR, Djoussé, L, Ix, JH, Siscovick, D, Tracy, RP, Thielke, SM, Hirsch, C, Newman, AB, Zieman, S |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 69 |
| Issue | 6 |
| Pagination | 710-6 |
| Date Published | 2014 Jun |
| ISSN | 1758-535X |
| Keywords | Activities of Daily Living, Aged, Aged, 80 and over, Aging, Biomarkers, Cardiac Rehabilitation, Cardiovascular Diseases, Disabled Persons, Female, Follow-Up Studies, Frail Elderly, Health Status, Humans, Incidence, Lysine, Male, Prevalence, Prognosis, Retrospective Studies, United States |
| Abstract | <p><b>BACKGROUND: </b>Advanced glycation endproducts are biologically active compounds that accumulate in disordered metabolism and normal aging. Carboxymethyl-lysine (CML), a ubiquitous human advanced glycation endproduct, has been associated with age-related conditions and mortality. Our objective was to ascertain the relationship between CML and geriatric outcomes (disability and frailty) in a large cohort of older men and women.</p><p><b>METHODS: </b>In 1996-1997, serum CML was measured in 3,373 Cardiovascular Health Study participants (mean age 78.1 ± 4.8 years). Disability, defined as difficulty in any of six activities of daily living, was assessed every 6-12 months for 14 years. Frailty was defined according to five standard criteria at the 1996-1997 visit. Cox proportional hazard models estimated the relationship between CML and incident disability (N = 2,643). Logistic regression models estimated the relationship between CML and prevalent frailty.</p><p><b>RESULTS: </b>Adjusting for multiple potential confounders, higher CML was associated with incident disability (hazard ratio per standard deviation [225 ng/mL] increase: 1.05, 95% CI 1.01-1.11). In men, odds of frailty increased with higher CML values (odds ratio = 1.30 per standard deviation, 95% CI 1.14-1.48), but the relationship was attenuated by adjustment for cognitive status, kidney function, and arthritis. CML was not associated with frailty in women.</p><p><b>CONCLUSIONS: </b>Higher serum CML levels in late life are associated with incident disability and prevalent frailty. Further work is needed to understand CML's value as a risk stratifier, biomarker, or target for interventions that promote healthy aging.</p> |
| DOI | 10.1093/gerona/glt155 |
| Alternate Journal | J. Gerontol. A Biol. Sci. Med. Sci. |
| PubMed ID | 24127427 |
| PubMed Central ID | PMC4022092 |
| Grant List | P30 AG024827 / AG / NIA NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States 268200800007C / / PHS HHS / United States 268201200036C / / PHS HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States HL094555 / HL / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States K23 AG032867 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States P30 AG028716 / AG / NIA NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States 5P30AG028716 / AG / NIA NIH HHS / United States |