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Plasma Fatty Acid binding protein 4 and risk of sudden cardiac death in older adults.
Wednesday,2014-01-29 11:23 America/Los_Angeles — poolea2
| Title | Plasma Fatty Acid binding protein 4 and risk of sudden cardiac death in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Djoussé, L, Maziarz, M, Biggs, ML, Ix, JH, Zieman, SJ, Kizer, JR, Lemaitre, RN, Mozaffarian, D, Tracy, RP, Mukamal, KJ, Siscovick, DS, Sotoodehnia, N |
| Journal | Cardiol Res Pract |
| Volume | 2013 |
| Pagination | 181054 |
| Date Published | 2013 |
| ISSN | 2090-8016 |
| Abstract | <p>Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated through review of medical records. We used Cox proportional hazards to estimate effect measures. During a median followup of 11.8 years, 146 SCD cases occurred. In a multivariable model adjusting for demographic, lifestyle, and metabolic factors, relative risk of SCD associated with each higher standard deviation (SD) of plasma FABP4 was 1.15 (95% CI: 0.95-1.38), P = 0.15. In a secondary analysis stratified by prevalent diabetes status, FABP4 was associated with higher risk of SCD in nondiabetic participants, (RR per SD higher FABP4: 1.33 (95% CI: 1.07-1.65), P = 0.009) but not in diabetic participants (RR per SD higher FABP4: 0.88 (95% CI: 0.62-1.27), P = 0.50), P for diabetes-FABP4 interaction 0.049. In summary, a single measure of plasma FABP4 obtained later in life was not associated with the risk of SCD in older adults overall. Confirmation of our post-hoc results in nondiabetic people in other studies is warranted. </p> |
| DOI | 10.1155/2013/181054 |
| Alternate Journal | Cardiol Res Pract |
| PubMed ID | 24455402 |
| PubMed Central ID | PMC3888692 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01 HL094555 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |