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Effects of varying approaches for identifying respiratory disturbances on sleep apnea assessment.
Tuesday,2012-11-06 12:04 America/Los_Angeles — eenright
| Title | Effects of varying approaches for identifying respiratory disturbances on sleep apnea assessment. |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Redline, S, Kapur, VK, Sanders, MH, Quan, SF, Gottlieb, DJ, Rapoport, DM, Bonekat, WH, Smith, PL, Kiley, JP, Iber, C |
| Journal | Am J Respir Crit Care Med |
| Volume | 161 |
| Issue | 2 Pt 1 |
| Pagination | 369-74 |
| Date Published | 2000 Feb |
| ISSN | 1073-449X |
| Keywords | Adult, Aged, Aged, 80 and over, Arousal, Diagnosis, Differential, Female, Humans, Lung Volume Measurements, Male, Middle Aged, Observer Variation, Oxygen, Oxyhemoglobins, Polysomnography, Risk Factors, Sleep Apnea Syndromes |
| Abstract | <p>Varying approaches to measuring the respiratory disturbance index (RDI) may lead to discrepant estimates of the severity of sleep-disordered breathing (SDB). In this study, we assessed the impact of varying the use of corroborative data (presence and degree of desaturation and/or arousal) to identify hypopneas and apneas. The relationships among 10 RDIs defined by various definitions of apneas and hypopneas were assessed in 5,046 participants in the Sleep Heart Health Study (SHHS) who underwent overnight unattended 12-channel polysomnography (PSG). The magnitude of the median RDI varied 10-fold (i.e., 29.3 when the RDI was based on events identified on the basis of flow or volume amplitude criteria alone to 2.0 for an RDI that required an associated 5% desaturation with events). The correlation between RDIs based on different definitions ranged from 0.99 to 0.68. The highest correlations were among RDIs that required apneas and hypopneas to be associated with some level of desaturation. Lower correlations were observed between RDIs that required desaturation as compared with RDIs defined on the basis of amplitude criteria alone or associated arousal. These data suggest that different approaches for measuring the RDI may contribute to substantial variability in identification and classification of the disorder.</p> |
| DOI | 10.1164/ajrccm.161.2.9904031 |
| Alternate Journal | Am J Respir Crit Care Med |
| PubMed ID | 10673173 |
| Grant List | U01 HL053938 / HL / NHLBI NIH HHS / United States U01HL53940 / HL / NHLBI NIH HHS / United States U01HL53941 / HL / NHLBI NIH HHS / United States UO1HL53938 / HL / NHLBI NIH HHS / United States |