You are here
Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study.
Monday,2013-09-30 16:45 America/Los_Angeles — poolea2
| Title | Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Fesinmeyer, MD, North, KE, Lim, U, Bůzková, P, Crawford, DC, Haessler, J, Gross, MD, Fowke, JH, Goodloe, R, Love, S-A, Graff, M, Carlson, CS, Kuller, LH, Matise, TC, Hong, C-P, Henderson, BE, Allen, M, Rohde, RR, Mayo, P, Schnetz-Boutaud, N, Monroe, KR, Ritchie, MD, Prentice, RL, Kolonel, LN, Manson, JAE, Pankow, J, Hindorff, LA, Franceschini, N, Wilkens, LR, Haiman, CA, Le Marchand, L, Peters, U |
| Journal | BMC Med Genet |
| Volume | 14 |
| Pagination | 6 |
| Date Published | 2013 Jan 11 |
| ISSN | 1471-2350 |
| Keywords | Adolescent, Adult, African Americans, Aged, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Body Mass Index, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Humans, Male, Membrane Proteins, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Proteins, Risk Factors, Smoking, Young Adult |
| Abstract | <p><b>BACKGROUND: </b>Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.</p><p><b>METHODS: </b>As part of the 'Population Architecture using Genomics and Epidemiology (PAGE)' Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses.</p><p><b>RESULTS: </b>We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/TMEM18, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, p(interaction) = 0.10). For rs9939609/FTO, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5 x 10(-5)), vs. former/never smokers (β = 0.006, p = 0.05, p(interaction) = 0.08).</p><p><b>CONCLUSIONS: </b>These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results.</p><p><b>CLINICAL TRIAL REGISTRATION: </b>NCT00000611.</p> |
| DOI | 10.1186/1471-2350-14-6 |
| Alternate Journal | BMC Med. Genet. |
| PubMed ID | 23311614 |
| PubMed Central ID | PMC3564691 |
| Grant List | N01-HC-45205 / HC / NHLBI NIH HHS / United States P30 ES010126 / ES / NIEHS NIH HHS / United States N01WH22110 / WH / WHI NIH HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States U01CA98758 / CA / NCI NIH HHS / United States U01 HL65520 / HL / NHLBI NIH HHS / United States N01WH42129-32 / WH / WHI NIH HHS / United States N01-HV-48195 / HV / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States U01 HG004790 / HG / NHGRI NIH HHS / United States N01-HC-48047 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States U01 HL41642 / HL / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01WH32100-2 / WH / WHI NIH HHS / United States AG-15928 / AG / NIA NIH HHS / United States U01CA136792 / CA / NCI NIH HHS / United States N01WH32108-9 / WH / WHI NIH HHS / United States U01HG004803 / HG / NHGRI NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States N01-HC-95095 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States U01HG004802 / HG / NHGRI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01WH42107-26 / WH / WHI NIH HHS / United States N01-HC-48050 / HC / NHLBI NIH HHS / United States U01 HL41654 / HL / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-45134 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States U01 HL41652 / HL / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01WH32122 / WH / WHI NIH HHS / United States U01HL65521 / HL / NHLBI NIH HHS / United States N01-HC-48049 / HC / NHLBI NIH HHS / United States U01HG004798-01 / HG / NHGRI NIH HHS / United States U01HG004798 / HG / NHGRI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01 HC-15103 / HC / NHLBI NIH HHS / United States N01WH32105-6 / WH / WHI NIH HHS / United States N01WH32111-13 / WH / WHI NIH HHS / United States N01WH32118-32119 / WH / WHI NIH HHS / United States U01HG004801 / HG / NHGRI NIH HHS / United States R37CA54281 / CA / NCI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States U01HG004790 / HG / NHGRI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States U01HG004801-01 / HG / NHGRI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States N01-HC-48048 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States R24 HD050924 / HD / NICHD NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01WH32115 / WH / WHI NIH HHS / United States P30 CA071789 / CA / NCI NIH HHS / United States N01WH44221 / WH / WHI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States P01CA33619 / CA / NCI NIH HHS / United States N01WH24152 / WH / WHI NIH HHS / United States R01 CA63 / CA / NCI NIH HHS / United States |