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Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study.
Monday,2013-04-22 14:21 America/Los_Angeles — eenright
| Title | Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Odden, MC, Tager, IB, Gansevoort, RT, Bakker, SJL, Fried, LF, Newman, AB, Katz, R, Satterfield, S, Harris, TB, Sarnak, MJ, Siscovick, D, Shlipak, MG |
| Journal | Ann Epidemiol |
| Volume | 23 |
| Issue | 3 |
| Pagination | 106-11 |
| Date Published | 2013 Mar |
| ISSN | 1873-2585 |
| Keywords | Adult, Age Factors, Aged, Aged, 80 and over, Aging, Causality, Cholesterol, LDL, Cohort Studies, Comorbidity, Cross-Sectional Studies, Cystatin C, Female, Humans, Hypertension, Kidney Function Tests, Male, Netherlands, Obesity, Prevalence, Renal Insufficiency, Chronic, Risk Factors, Smoking, United States |
| Abstract | <p><b>PURPOSE: </b>To determine if the associations among established risk factors and reduced kidney function vary by age.</p><p><b>METHODS: </b>We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort.</p><p><b>RESULTS: </b>Hypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertension was associated with a 2.3 (95% confidence interval [CI], 0.1, 4.4), 5.1 (95% CI, 4.1, 6.1), and 6.9 (95% CI, 3.0, 10.4) mL/min/1.73 m(2) lower eGFR in participants 40 to 59, 60 to 79, and at least 80 years, respectively (P for interaction < .001). The association of low HDL cholesterol with reduced kidney function was also greater in the older age groups: 4.9 (95% CI, 3.5, 6.3), 7.1 (95% CI, 6.0, 8.3), 8.9 (95% CI, 5.4, 11.9) mL/min/1.73 m(2) (P for interaction < .001). Smoking and obesity were associated with reduced kidney function in participants under 80 years. All estimates of the potential population impact of the risk factors were modest.</p><p><b>CONCLUSIONS: </b>Hypertension, obesity, smoking, and low HDL cholesterol are modestly associated with reduced kidney function in nondiabetics. The associations of hypertension and HDL cholesterol with reduced kidney function seem to be stronger in older adults.</p> |
| DOI | 10.1016/j.annepidem.2012.12.004 |
| Alternate Journal | Ann Epidemiol |
| PubMed ID | 23313266 |
| PubMed Central ID | PMC3570601 |
| Grant List | R01AG027002 / AG / NIA NIH HHS / United States R01-AG028050 / AG / NIA NIH HHS / United States N01-AG-6-2101 / AG / NIA NIH HHS / United States N01-AG-6-2103 / AG / NIA NIH HHS / United States R01-NR012459 / NR / NINR NIH HHS / United States K01 AG039387 / AG / NIA NIH HHS / United States N01-HC-95159 / HC / NHLBI NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States N01-HC-95165 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States / / Intramural NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States R01-HL-63963-01A1 / HL / NHLBI NIH HHS / United States N01-HC-95169 / HC / NHLBI NIH HHS / United States DK52866 / DK / NIDDK NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-AG-6-2106 / AG / NIA NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States T32DK07791 / DK / NIDDK NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States K01AG039387 / AG / NIA NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |