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High density lipoprotein cholesterol is associated with serum cortisol in older people.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | High density lipoprotein cholesterol is associated with serum cortisol in older people. |
| Publication Type | Journal Article |
| Year of Publication | 1995 |
| Authors | Varma, VK, Rushing, JT, Ettinger, WH |
| Journal | J Am Geriatr Soc |
| Volume | 43 |
| Issue | 12 |
| Pagination | 1345-9 |
| Date Published | 1995 Dec |
| ISSN | 0002-8614 |
| Keywords | Aged, Body Constitution, Body Mass Index, Cardiovascular Diseases, Carotid Stenosis, Cholesterol, HDL, Coronary Disease, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Hydrocortisone, Hypertension, Male, Prevalence, Risk Factors |
| Abstract | <p><b>OBJECTIVE: </b>To determine the associations between serum cortisol and HDL cholesterol, other lipoprotein lipids and cardiovascular risk factors, carotid atherosclerosis, and clinical heart disease in older people.</p><p><b>DESIGN: </b>A cross-sectional, observational, ancillary study of the Cardiovascular Health Study (CHS).</p><p><b>POPULATION: </b>A total of 245 community-dwelling people, 65 to 89 years old, were recruited consecutively for a 2-month period from the CHS cohort in Forsyth County, North Carolina.</p><p><b>METHODS: </b>Cortisol was measured by radioimmunoassay in serum collected between 7:00 and 10:00 AM after an overnight fast. Cortisol levels were correlated with lipoprotein lipids, insulin, glucose, body mass index, waist-hip ratio, prevalent coronary heart disease, hypertension, diabetes, and carotid atherosclerosis by B-mode ultrasound.</p><p><b>RESULTS: </b>Serum cortisol was correlated negatively (r = -.24) with body mass index and waist-hip ratio (r = -.16) but was not related significantly to fasting insulin or glucose. Cortisol was not associated significantly with triglyceride and low density lipoprotein cholesterol but showed a positive correlation (r = .21) with high density lipoprotein cholesterol. The relationship between cortisol and high density lipoprotein cholesterol persisted after adjustment for gender, body mass index, waist-hip ratio, cigarette and alcohol use, triglyceride level, and diabetes. There was a trend toward a negative correlation between cortisol and measures of carotid atherosclerosis, but no significant relationship was indicated between cortisol and prevalent coronary heart disease, hypertension, or diabetes.</p><p><b>CONCLUSION: </b>Endogenous glucocorticoid levels correlated with HDL cholesterol levels and may play a role in the physiologic regulation of high density lipoprotein levels in older people.</p> |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 7490384 |
| Grant List | K07AG00421 / AG / NIA NIH HHS / United States P60AG10484 / AG / NIA NIH HHS / United States T32AG00182 / AG / NIA NIH HHS / United States |