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Heart rate response to a timed walk and cardiovascular outcomes in older adults: the cardiovascular health study.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | Heart rate response to a timed walk and cardiovascular outcomes in older adults: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Girotra, S, Kitzman, DW, Kop, WJ, Stein, PK, Gottdiener, JS, Mukamal, KJ |
| Journal | Cardiology |
| Volume | 122 |
| Issue | 2 |
| Pagination | 69-75 |
| Date Published | 2012 |
| ISSN | 1421-9751 |
| Keywords | Aged, Cause of Death, Coronary Disease, Exercise Test, Female, Heart Rate, Humans, Male, Physical Exertion, Prognosis, Prospective Studies, Risk Factors, Time Factors, Walking |
| Abstract | <p><b>OBJECTIVES: </b>To determine the relationship between heart rate response during low-grade physical exertion (6-min walk) with mortality and adverse cardiovascular outcomes in the elderly.</p><p><b>METHODS: </b>Participants in the Cardiovascular Health Study who completed a 6-min walk test were included. We used delta heart rate (difference between postwalk heart rate and resting heart rate) as a measure of chronotropic response and examined its association with (1) all-cause mortality and (2) incident coronary heart disease event, using multivariable Cox regression models.</p><p><b>RESULTS: </b>We included 2,224 participants (mean age 77 ± 4 years; 60% women; 85% white). The average delta heart rate was 26 beats/min. Participants in the lowest tertile of delta heart rate (<20 beats/min) had higher risk-adjusted mortality [hazard ratio (HR) 1.18, 95% confidence interval (CI) 1.00-1.40] and incident coronary heart disease (HR 1.37, 95% CI 1.05-1.78) compared to subjects in the highest tertile (≥30 beats/min), with a significant linear trend across tertiles (p for trend <0.05 for both outcomes). This relationship was not significant after adjustment for distance walked.</p><p><b>CONCLUSION: </b>Impaired chronotropic response during a 6-min walk test was associated with an increased risk of mortality and incident coronary heart disease among the elderly. This association was attenuated after adjusting for distance walked.</p> |
| DOI | 10.1159/000338736 |
| Alternate Journal | Cardiology |
| PubMed ID | 22722364 |
| PubMed Central ID | PMC3516408 |
| Grant List | R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R37 AG018915 / AG / NIA NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States R01 AG018915 / AG / NIA NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States / / Intramural NIH HHS / United States R01 HL062181 / HL / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States P30 AG021332 / AG / NIA NIH HHS / United States |