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Surrogate screening models for the low physical activity criterion of frailty.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | Surrogate screening models for the low physical activity criterion of frailty. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Eckel, SP, Bandeen-Roche, K, Chaves, PHM, Fried, LP, Louis, TA |
| Journal | Aging Clin Exp Res |
| Volume | 23 |
| Issue | 3 |
| Pagination | 209-16 |
| Date Published | 2011 Jun |
| ISSN | 1594-0667 |
| Keywords | Activities of Daily Living, Aged, Cohort Studies, Exercise, Female, Follow-Up Studies, Frail Elderly, Geriatric Assessment, Humans, Leisure Activities, Logistic Models, Male, Motor Activity, Prospective Studies, Surveys and Questionnaires, Women's Health |
| Abstract | <p><b>BACKGROUND AND AIMS: </b>Low physical activity, one of five criteria in a validated clinical phenotype of frailty, is assessed by a standardized, semiquantitative questionnaire on up to 20 leisure time activities. Because of the time demanded to collect the interview data, it has been challenging to translate to studies other than the Cardiovascular Health Study (CHS), for which it was developed. Considering subsets of activities, we identified and evaluated streamlined surrogate assessment methods and compared them to one implemented in the Women's Health and Aging Study (WHAS).</p><p><b>METHODS: </b>Using data on men and women ages 65 and older from the CHS, we applied logistic regression models to rank activities by "relative influence" in predicting low physical activity.We considered subsets of the most influential activities as inputs to potential surrogate models (logistic regressions). We evaluated predictive accuracy and predictive validity using the area under receiver operating characteristic curves and assessed criterion validity using proportional hazards models relating frailty status (defined using the surrogate) to mortality.</p><p><b>RESULTS: </b>Walking for exercise and moderately strenuous household chores were highly influential for both genders. Women required fewer activities than men for accurate classification. The WHAS model (8 CHS activities) was an effective surrogate, but a surrogate using 6 activities (walking, chores, gardening, general exercise, mowing and golfing) was also highly predictive.</p><p><b>CONCLUSIONS: </b>We recommend a 6 activity questionnaire to assess physical activity for men and women. If efficiency is essential and the study involves only women, fewer activities can be included.</p> |
| Alternate Journal | Aging Clin Exp Res |
| PubMed ID | 21993168 |
| PubMed Central ID | PMC3351838 |
| Grant List | R01 DK061662 / DK / NIDDK NIH HHS / United States R01 AG011703 / AG / NIA NIH HHS / United States R24 HD042854 / HD / NICHD NIH HHS / United States T32 AG000247 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 AG012112 / AG / NIA NIH HHS / United States WHAS2-R01AG11703 / AG / NIA NIH HHS / United States R37 AG019905 / AG / NIA NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States WHAS3-1R37AG19905 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States T32 AG00247 / AG / NIA NIH HHS / United States WHAS1-N01AG12112 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |