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White matter lesions and brain gray matter volume in cognitively normal elders.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | White matter lesions and brain gray matter volume in cognitively normal elders. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Raji, CA, Lopez, OL, Kuller, LH, Carmichael, OT, Longstreth, WT, H Gach, M, Boardman, J, Bernick, CB, Thompson, PM, Becker, JT |
| Journal | Neurobiol Aging |
| Volume | 33 |
| Issue | 4 |
| Pagination | 834.e7-16 |
| Date Published | 2012 Apr |
| ISSN | 1558-1497 |
| Keywords | Aged, Aged, 80 and over, Aging, Apolipoprotein E4, Brain, Cognition Disorders, Female, Humans, Imaging, Three-Dimensional, Leukoaraiosis, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory Disorders, Mental Status Schedule, Neuropsychological Tests, Regression Analysis, Retrospective Studies |
| Abstract | <p>Cerebral white matter lesions (WMLs) reflect small vessel disease, are common in elderly individuals, and are associated with cognitive impairment. We sought to determine the relationships between WMLs, age, gray matter (GM) volume, and cognition in the Cardiovascular Health Study (CHS). From the Cardiovascular Health Study we selected 740 cognitively normal controls with a 1.5 T magnetic resonance imaging (MRI) scan of the brain and a detailed diagnostic evaluation. WML severity was determined using a standardized visual rating system. GM volumes were analyzed using voxel-based morphometry implemented in the Statistical Parametric Mapping software. WMLs were inversely correlated with GM volume, with the greatest volume loss in the frontal cortex. Age-related atrophy was observed in the hippocampus and posterior cingulate cortex. Regression analyses revealed links among age, APOE*4 allele, hypertension, WMLs, GM volume, and digit symbol substitution test scores. Both advancing age and hypertension predict higher WML load, which is itself associated with GM atrophy. Longitudinal data are needed to confirm the temporal sequence of events leading to a decline in cognitive function.</p> |
| DOI | 10.1016/j.neurobiolaging.2011.08.010 |
| Alternate Journal | Neurobiol. Aging |
| PubMed ID | 21943959 |
| PubMed Central ID | PMC3248984 |
| Grant List | N01 HC085086 / HC / NHLBI NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States R01 AG015928-02 / AG / NIA NIH HHS / United States R01 EB002172-05 / EB / NIBIB NIH HHS / United States N01-HC-80007 / HC / NHLBI NIH HHS / United States N01 HC085081 / HC / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC075150 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC085083 / HC / NHLBI NIH HHS / United States AG020098 / AG / NIA NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States N01 HC085085 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States P50 AG005133-25 / AG / NIA NIH HHS / United States N01 HC085082 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01 HC085080 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States AG05133 / AG / NIA NIH HHS / United States N01 HC055222 / HC / NHLBI NIH HHS / United States N01-HC-055222 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States N01 HC085084 / HC / NHLBI NIH HHS / United States EB008281 / EB / NIBIB NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States R01 EB008281 / EB / NIBIB NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States R01 EB002172 / EB / NIBIB NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R01 AG020098-05 / AG / NIA NIH HHS / United States |