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Risk factors for onset of disability among older persons newly diagnosed with heart failure: the Cardiovascular Health Study.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | Risk factors for onset of disability among older persons newly diagnosed with heart failure: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Chaudhry, SI, McAvay, G, Ning, Y, Allore, HG, Newman, AB, Gill, TM |
| Journal | J Card Fail |
| Volume | 17 |
| Issue | 9 |
| Pagination | 764-70 |
| Date Published | 2011 Sep |
| ISSN | 1532-8414 |
| Keywords | Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Disability Evaluation, Disabled Persons, Female, Health Status, Heart Failure, Humans, Longitudinal Studies, Male, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>As the heart failure population continues to age, disability is becoming an increasingly important issue. Our objective was to identify risk factors for the onset of disability in activities of daily living among older persons with heart failure.</p><p><b>METHODS: </b>The study population included participants with newly diagnosed heart failure from the Cardiovascular Health Study, a longitudinal study of community-living, older persons. Data were collected through annual examinations. Cox regression modeling was used to examine associations between time-dependent predictors and onset of disability.</p><p><b>RESULTS: </b>Of 461 participants newly diagnosed with heart failure (mean age 78.7 [SD 5.89]), 23% subsequently developed disability. The first year after heart failure diagnosis was the period of greatest risk for onset of disability (chi-square P value <.001). Factors that were independently associated with disability included: impaired gait speed (HR 2.29, 95% CI 1.34-3.90); impaired cognition (HR 1.87, 95% CI 1.14-3.05); and depressive symptoms (HR 1.72, 95% CI 1.04-2.83).</p><p><b>CONCLUSIONS: </b>Onset of disability is a common occurrence among older persons newly diagnosed with heart failure. Risk factors for onset of disability in this population are potentially modifiable, and should be routinely assessed in an effort to reduce disability in this growing population.</p> |
| DOI | 10.1016/j.cardfail.2011.04.015 |
| Alternate Journal | J. Card. Fail. |
| PubMed ID | 21872147 |
| PubMed Central ID | PMC3164529 |
| Grant List | P30 AG024827 / AG / NIA NIH HHS / United States R01 AG-15928 / AG / NIA NIH HHS / United States UL1 TR000005 / TR / NCATS NIH HHS / United States R01 HL075366 / HL / NHLBI NIH HHS / United States N01-HC-80007 / HC / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 HL-075366 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States P30AG21342 / AG / NIA NIH HHS / United States P30-AG-024827 / AG / NIA NIH HHS / United States K24 AG021507-01 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States K23 AG030986-01A1 / AG / NIA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States P30 AG021342 / AG / NIA NIH HHS / United States K23AG030986 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01 AG-20098 / AG / NIA NIH HHS / United States K24AG021507 / AG / NIA NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States K24 AG021507 / AG / NIA NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States K23 AG030986 / AG / NIA NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States |