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Plasma omega-3 fatty acids and incident diabetes in older adults.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | Plasma omega-3 fatty acids and incident diabetes in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Djoussé, L, Biggs, ML, Lemaitre, RN, King, IB, Song, X, Ix, JH, Mukamal, KJ, Siscovick, DS, Mozaffarian, D |
| Journal | Am J Clin Nutr |
| Volume | 94 |
| Issue | 2 |
| Pagination | 527-33 |
| Date Published | 2011 Aug |
| ISSN | 1938-3207 |
| Keywords | Aged, Aged, 80 and over, alpha-Linolenic Acid, Diabetes Mellitus, Fatty Acids, Omega-3, Female, Humans, Male, Phospholipids, Proportional Hazards Models, Prospective Studies |
| Abstract | <p><b>BACKGROUND: </b>Although long-chain omega-3 fatty acid (n-3 FA) consumption estimated via food-frequency questionnaires has been associated with a higher incidence of diabetes, limited prospective data on diabetes risk are available that use objective biomarkers of n-3 FAs.</p><p><b>OBJECTIVE: </b>We sought to examine the relation between plasma phospholipid n-3 FAs and incident diabetes.</p><p><b>DESIGN: </b>We prospectively analyzed data in 3088 older men and women (mean age: 75 y) from the Cardiovascular Health Study (1992-2007). Plasma phospholipid n-3 FAs were measured by using gas chromatography, and incident diabetes was ascertained by using information on hypoglycemic agents and serum glucose. We used Cox proportional hazards models to estimate multivariable-adjusted relative risks.</p><p><b>RESULTS: </b>During a median follow-up of 10.6 y, 204 new cases of diabetes occurred. In a multivariable model that controlled for age, sex, race, clinic site, body mass index, alcohol intake, smoking, physical activity, LDL cholesterol, and linoleic acid, relative risks (95% CIs) for diabetes were 1.0 (reference), 0.96 (0.65, 1.43), 1.03 (0.69, 1.54), and 0.64 (0.41, 1.01) across consecutive quartiles of phospholipid eicosapentaenoic acid and docosahexaenoic acid (P for trend = 0.05). Corresponding relative risks (95% CIs) for phospholipid α-linolenic acid (ALA) were 1.0 (reference), 0.93 (0.65, 1.34), 0.99 (0.68, 1.44), and 0.57 (0.36, 0.90) (P for trend = 0.03).</p><p><b>CONCLUSIONS: </b>With the use of objective biomarkers, long-chain n-3 FAs and ALA were not associated with a higher incidence of diabetes. Individuals with the highest concentrations of both types of FAs had lower risk of diabetes.</p> |
| DOI | 10.3945/ajcn.111.013334 |
| Alternate Journal | Am. J. Clin. Nutr. |
| PubMed ID | 21593500 |
| PubMed Central ID | PMC3142727 |
| Grant List | N01-HC- 35129 / HC / NHLBI NIH HHS / United States P30 AG024827 / AG / NIA NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States R01 HL-075366 / HL / NHLBI NIH HHS / United States AG-15928 / AG / NIA NIH HHS / United States P30-AG-024827 / AG / NIA NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01 HC-15103 / HC / NHLBI NIH HHS / United States R01 HL 085710-01 / HL / NHLBI NIH HHS / United States R01 HL094555 / HL / NHLBI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States |