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Mineral metabolism markers and the long-term risk of hip fracture: the cardiovascular health study.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | Mineral metabolism markers and the long-term risk of hip fracture: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Robinson-Cohen, C, Katz, R, Hoofnagle, AN, Cauley, JA, Furberg, CD, Robbins, JA, Chen, Z, Siscovick, DS, de Boer, IH, Kestenbaum, B |
| Journal | J Clin Endocrinol Metab |
| Volume | 96 |
| Issue | 7 |
| Pagination | 2186-93 |
| Date Published | 2011 Jul |
| ISSN | 1945-7197 |
| Keywords | Aged, Aged, 80 and over, Alkaline Phosphatase, Biomarkers, Bone Density, Female, Hip Fractures, Humans, Male, Parathyroid Hormone, Risk, Vitamin D |
| Abstract | <p><b>CONTEXT: </b>Disturbances in mineral metabolism are associated with lower bone mineral density and fracture; however, previous human studies have assessed individual mineral metabolism markers in isolation.</p><p><b>OBJECTIVE: </b>We assessed serum concentrations of 25-hydroxyvitamin D (25-OHD), PTH, and bone-specific alkaline phosphatase (BAP) concentrations individually, and in combination, in association with the long-term risk of hip fracture among a general population of older adults.</p><p><b>DESIGN AND SETTING: </b>We studied 2294 participants from the Cardiovascular Health Study (mean age 74 yr) who were ambulatory and free of hip fracture and known cardiovascular disease at baseline. We used proportional hazards models to evaluate associations of baseline serum 25-OHD, PTH, and BAP concentrations with the time to first hospitalized hip fracture.</p><p><b>RESULTS: </b>During a median of 13 yr of follow-up, 242 participants (10.6%) developed an incident hip fracture. Serum 25-OHD concentrations less than 15 ng/ml were associated with a 61% greater adjusted risk of fracture (95% confidence interval 12-132% greater). In contrast, neither serum PTH nor BAP concentrations were significantly associated with fracture risk. The association of 25-OHD deficiency with hip fracture was not significantly altered by either PTH or BAP concentrations.</p><p><b>CONCLUSIONS: </b>Serum concentrations of 25-OHD, but not PTH or BAP, are associated with long-term hip fracture risk among ambulatory older adults. These data suggest that 25-OHD is the most relevant mineral metabolism marker of fracture risk among older people.</p> |
| DOI | 10.1210/jc.2010-2878 |
| Alternate Journal | J. Clin. Endocrinol. Metab. |
| PubMed ID | 21508146 |
| PubMed Central ID | PMC3135189 |
| Grant List | R01AG027002 / AG / NIA NIH HHS / United States R01AG 0270 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R0 1HL084443 / HL / NHLBI NIH HHS / United States IR01 HL 084443-01A2 / HL / NHLBI NIH HHS / United States T32 AG000270 / AG / NIA NIH HHS / United States 1R01HL084443-01A2 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01 HL084443 / HL / NHLBI NIH HHS / United States R01 AG027002 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |