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Geriatric impairments and disability: the cardiovascular health study.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | Geriatric impairments and disability: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Chaudhry, SI, McAvay, G, Ning, Y, Allore, HG, Newman, AB, Gill, TM |
| Journal | J Am Geriatr Soc |
| Volume | 58 |
| Issue | 9 |
| Pagination | 1686-92 |
| Date Published | 2010 Sep |
| ISSN | 1532-5415 |
| Keywords | Activities of Daily Living, Aged, Aged, 80 and over, Cardiac Rehabilitation, Cardiovascular Diseases, Disabled Persons, Female, Follow-Up Studies, Geriatric Assessment, Health Status, Humans, Male, Morbidity, Retrospective Studies, Risk Factors, Time Factors, United States |
| Abstract | <p><b>OBJECTIVES: </b>To determine the relative importance of geriatric impairments (in muscle strength, physical capacity, cognition, vision, hearing, and psychological status) and chronic diseases in predicting subsequent functional disability in longitudinal analyses.</p><p><b>DESIGN: </b>Longitudinal data from the Cardiovascular Health Study were analyzed. Multivariable Cox hazards regression modeling was used to analyze associations between time-dependent predictors and onset of disability in activities of daily living (ADLs) and mobility.</p><p><b>SETTING: </b>Four communities across the United States (Sacramento County, CA; Washington County, MD; Forsyth County, NC; and Allegheny County, PA).</p><p><b>PARTICIPANTS: </b>Five thousand eight hundred eighty-eight elderly persons.</p><p><b>MEASUREMENTS: </b>Data were collected annually through in-person examinations.</p><p><b>RESULTS: </b>ADL disability developed in 15% of participants and mobility disability in 30%. A single multivariable model was developed that included demographics, marital status, body mass index, and number of impairments and diseases. The hazard ratios (HRs) of having one, two, and three or more geriatric impairments (vs none) for the outcome of ADL disability were 2.12 (95% confidence interval (CI)=1.63-2.75), 4.25 (95% CI=3.30-5.48), and 7.87 (95% CI=6.10-10.17), respectively, and for having one, two, and three or more chronic diseases were 1.75 (95% CI=1.41-2.19), 2.45 (95% CI=1.95-3.07), and 3.26 (95% CI=2.53-4.19), respectively. Similarly, the HRs of having one, two, and three or more impairments for the outcome of mobility disability were 1.48 (95% CI=1.27-1.73), 2.08 (95% CI=1.77-2.45), and 3.70 (95% CI=3.09-4.42), respectively, and for having one, two, and three or more diseases were 2.06 (95% CI=1.76-2.40), 2.80 (95% CI=2.36-3.31), and 4.20 (95% CI=3.44-5.14), respectively.</p><p><b>CONCLUSION: </b>Number of geriatric impairments was more strongly associated than number of chronic diseases with subsequent ADL disability and nearly as strongly associated with the subsequent mobility disability.</p> |
| DOI | 10.1111/j.1532-5415.2010.03022.x |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 20863328 |
| PubMed Central ID | PMC2946108 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States P30AG21342 / AG / NIA NIH HHS / United States K24 AG021507-01 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States K23 AG030986-01A1 / AG / NIA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States P30 AG021342 / AG / NIA NIH HHS / United States K23AG030986 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States K24AG021507 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States K24 AG021507 / AG / NIA NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States K23 AG030986 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |