CHS Home | Welcome New Investigators | Directory | Contact Us

 

You are here

Home

Genome-wide association study of PR interval.

Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
TitleGenome-wide association study of PR interval.
Publication TypeJournal Article
Year of Publication2010
AuthorsPfeufer, A, van Noord, C, Marciante, KD, Arking, DE, Larson, MG, Smith, AVernon, Tarasov, KV, Müller, M, Sotoodehnia, N, Sinner, MF, Verwoert, GC, Li, M, Kao, LWH, Köttgen, A, Coresh, J, Bis, JC, Psaty, BM, Rice, K, Rotter, JI, Rivadeneira, F, Hofman, A, Kors, JA, Stricker, BHC, Uitterlinden, AG, van Duijn, CM, Beckmann, BM, Sauter, W, Gieger, C, Lubitz, SA, Newton-Cheh, C, Wang, TJ, Magnani, JW, Schnabel, RB, Chung, MK, Barnard, J, Smith, JD, Van Wagoner, DR, Vasan, RS, Aspelund, T, Eiriksdottir, G, Harris, TB, Launer, LJ, Najjar, SS, Lakatta, E, Schlessinger, D, Uda, M, Abecasis, GR, Müller-Myhsok, B, Ehret, GB, Boerwinkle, E, Chakravarti, A, Soliman, EZ, Lunetta, KL, Perz, S, Wichmann, H-E, Meitinger, T, Levy, D, Gudnason, V, Ellinor, PT, Sanna, S, Kääb, S, Witteman, JCM, Alonso, A, Benjamin, EJ, Heckbert, SR
JournalNat Genet
Volume42
Issue2
Pagination153-9
Date Published2010 Feb
ISSN1546-1718
KeywordsAged, Atrial Fibrillation, Cohort Studies, Electrocardiography, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Conduction System, Humans, Male, Meta-Analysis as Topic
Abstract<p>The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 x 10(-8). At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.</p>
DOI10.1038/ng.517
Alternate JournalNat. Genet.
PubMed ID20062060
PubMed Central IDPMC2850197
Grant ListHL-076784 / HL / NHLBI NIH HHS / United States
K23 HL080025-05 / HL / NHLBI NIH HHS / United States
P50-HL077107 / HL / NHLBI NIH HHS / United States
U01-HG004402 / HG / NHGRI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
N01 HC055022 / HC / NHLBI NIH HHS / United States
N01 HC085086 / HC / NHLBI NIH HHS / United States
R01 HL090620-02 / HL / NHLBI NIH HHS / United States
R01-HL-086694 / HL / NHLBI NIH HHS / United States
P50 HL077107-059001 / HL / NHLBI NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
N01AG12100 / AG / NIA NIH HHS / United States
N01 AG012100 / AG / NIA NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01 HC085081 / HC / NHLBI NIH HHS / United States
R01 HL087652-03 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
N01-AG-1-2109 / AG / NIA NIH HHS / United States
N01 HC075150 / HC / NHLBI NIH HHS / United States
R01 HL104156 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
R01-HL-087641 / HL / NHLBI NIH HHS / United States
U01 HL080295-05 / HL / NHLBI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC085083 / HC / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
L30 HL097675-01 / HL / NHLBI NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
N02 HL64278 / HL / NHLBI NIH HHS / United States
N01 HC085085 / HC / NHLBI NIH HHS / United States
R01-HL-087652 / HL / NHLBI NIH HHS / United States
U01-HL-080295 / HL / NHLBI NIH HHS / United States
R01 NS017950-28 / NS / NINDS NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
R01 HL076784 / HL / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
R01 HL088456 / HL / NHLBI NIH HHS / United States
R01 HL090620 / HL / NHLBI NIH HHS / United States
HL-080025 / HL / NHLBI NIH HHS / United States
M01-RR-00425 / RR / NCRR NIH HHS / United States
R01 DK033651 / DK / NIDDK NIH HHS / United States
P30 DK063491-039004 / DK / NIDDK NIH HHS / United States
N01 HC085082 / HC / NHLBI NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
R01-HL-59367 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
R01 HL087641-03 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
N01 HC085080 / HC / NHLBI NIH HHS / United States
/ / Intramural NIH HHS / United States
L30 HL097675 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
263-MA-410953 / / PHS HHS / United States
6R01-NS-17950 / NS / NINDS NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01 HC055222 / HC / NHLBI NIH HHS / United States
N01-HC-55222 / HC / NHLBI NIH HHS / United States
R01 HL090620-01A1 / HL / NHLBI NIH HHS / United States
P30 DK063491-07 / DK / NIDDK NIH HHS / United States
U01 HL054512-13 / HL / NHLBI NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
R01 HL086694-03 / HL / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01 AG012109 / AG / NIA NIH HHS / United States
P30 DK063491-029004 / DK / NIDDK NIH HHS / United States
UL1-RR025005 / RR / NCRR NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
R01 HL088456-03 / HL / NHLBI NIH HHS / United States
N01 HC055021 / HC / NHLBI NIH HHS / United States
M01 RR000425 / RR / NCRR NIH HHS / United States
N01 HC085084 / HC / NHLBI NIH HHS / United States
R01 HL076784-05 / HL / NHLBI NIH HHS / United States
UL1 RR025005-01 / RR / NCRR NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
R01-HL-088456 / HL / NHLBI NIH HHS / United States
P30 DK063491-019004 / DK / NIDDK NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
AG-028321 / AG / NIA NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
R01 AG028321-04 / AG / NIA NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
R01 HL059367-09 / HL / NHLBI NIH HHS / United States
R01-HL-054512 / HL / NHLBI NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
P30 DK063491-049004 / DK / NIDDK NIH HHS / United States
N01-HC25195 / HC / NHLBI NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01 HC085079 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
R01 AG028321 / AG / NIA NIH HHS / United States
U01 HL054512 / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
R01-HL090620 / HL / NHLBI NIH HHS / United States
P50 HL077107 / HL / NHLBI NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
N01 HC055016 / HC / NHLBI NIH HHS / United States
K23 HL080025 / HL / NHLBI NIH HHS / United States
M01 RR000425-30S1 / RR / NCRR NIH HHS / United States
U01 HG004402-02 / HG / NHGRI NIH HHS / United States

© 2001 - 2020 CHS Coordinating Center University of Washington, Seattle, WA

Privacy | Terms