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Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
| Title | Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Hancock, DB, Eijgelsheim, M, Wilk, JB, Gharib, SA, Loehr, LR, Marciante, KD, Franceschini, N, van Durme, YMTA, Chen, T-H, R Barr, G, Schabath, MB, Couper, DJ, Brusselle, GG, Psaty, BM, van Duijn, CM, Rotter, JI, Uitterlinden, AG, Hofman, A, Punjabi, NM, Rivadeneira, F, Morrison, AC, Enright, PL, North, KE, Heckbert, SR, Lumley, T, Stricker, BHC, O'Connor, GT, London, SJ |
| Journal | Nat Genet |
| Volume | 42 |
| Issue | 1 |
| Pagination | 45-52 |
| Date Published | 2010 Jan |
| ISSN | 1546-1718 |
| Keywords | Databases, Genetic, Female, Forced Expiratory Volume, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Lung, Lung Diseases, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Spirometry, Vital Capacity |
| Abstract | <p>Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.</p> |
| DOI | 10.1038/ng.500 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 20010835 |
| PubMed Central ID | PMC2832852 |
| Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States M01-RR00425 / RR / NCRR NIH HHS / United States N02-HL-6-4278 / HL / NHLBI NIH HHS / United States N01-HC-25195 / HC / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States G0000934 / / Medical Research Council / United Kingdom U01 HL080295 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States R01 HL077612 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States N01-HC-85079 THROUGH N01-HC-85086 / HC / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States RC1 HL100543 / HL / NHLBI NIH HHS / United States HHSN268200625226C / / PHS HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States M01 RR000425 / RR / NCRR NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States Z01 ES043012 / ES / NIEHS NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States DK063491 / DK / NIDDK NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States ZIA ES043012-11 / / Intramural NIH HHS / United States N01 HC095159 / HC / NHLBI NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States |