You are here
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Tuesday,2012-11-06 12:18 America/Los_Angeles — eenright
| Title | Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Benjamin, EJ, Rice, KM, Arking, DE, Pfeufer, A, van Noord, C, Smith, AV, Schnabel, RB, Bis, JC, Boerwinkle, E, Sinner, MF, Dehghan, A, Lubitz, SA, D'Agostino, RB, Lumley, T, Ehret, GB, Heeringa, J, Aspelund, T, Newton-Cheh, C, Larson, MG, Marciante, KD, Soliman, EZ, Rivadeneira, F, Wang, TJ, Eiriksdottir, G, Levy, D, Psaty, BM, Li, M, Chamberlain, AM, Hofman, A, Vasan, RS, Harris, TB, Rotter, JI, Kao, LWH, Agarwal, SK, Stricker, BHCh, Wang, K, Launer, LJ, Smith, NL, Chakravarti, A, Uitterlinden, AG, Wolf, PA, Sotoodehnia, N, Köttgen, A, van Duijn, CM, Meitinger, T, Mueller, M, Perz, S, Steinbeck, G, Wichmann, H-E, Lunetta, KL, Heckbert, SR, Gudnason, V, Alonso, A, Kääb, S, Ellinor, PT, Witteman, JCM |
| Journal | Nat Genet |
| Volume | 41 |
| Issue | 8 |
| Pagination | 879-81 |
| Date Published | 2009 Aug |
| ISSN | 1546-1718 |
| Keywords | Atrial Fibrillation, Chromosomes, Human, Pair 16, European Continental Ancestry Group, Genetic Predisposition to Disease, Genome-Wide Association Study, Homeodomain Proteins, Humans, Meta-Analysis as Topic, Mutation, Polymorphism, Single Nucleotide, Reproducibility of Results |
| Abstract | <p>We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).</p> |
| DOI | 10.1038/ng.416 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 19597492 |
| PubMed Central ID | PMC2761746 |
| Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States R01 AG028321-01 / AG / NIA NIH HHS / United States N01 HC055022 / HC / NHLBI NIH HHS / United States N01 HC085086 / HC / NHLBI NIH HHS / United States R01 HL059367-02 / HL / NHLBI NIH HHS / United States P30 DK063491-05 / DK / NIDDK NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States R01 HL088456-01 / HL / NHLBI NIH HHS / United States N01AG12100 / AG / NIA NIH HHS / United States T32 HL007575-23 / HL / NHLBI NIH HHS / United States N01 AG012100 / AG / NIA NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States N01 HC085081 / HC / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States U01 HG004402-01 / HG / NHGRI NIH HHS / United States R01 HL093328-01 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC075150 / HC / NHLBI NIH HHS / United States R01 HL104156 / HL / NHLBI NIH HHS / United States R01 HL092577 / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States M01 RR000069 / RR / NCRR NIH HHS / United States N01 HC085083 / HC / NHLBI NIH HHS / United States N01 HC055018 / HC / NHLBI NIH HHS / United States P30 DK063491-06 / DK / NIDDK NIH HHS / United States N01 HC025195 / HC / NHLBI NIH HHS / United States T32 HL007575 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States U01 HL080295-01 / HL / NHLBI NIH HHS / United States R01 HL080124-01 / HL / NHLBI NIH HHS / United States N02 HL64278 / HL / NHLBI NIH HHS / United States N01 HC085085 / HC / NHLBI NIH HHS / United States R01 HL087652-01 / HL / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States R01 HL076784 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01 HL086694-01A1 / HL / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL088456 / HL / NHLBI NIH HHS / United States R01 DK033651 / DK / NIDDK NIH HHS / United States P30 DK063491-039004 / DK / NIDDK NIH HHS / United States N01 HC085082 / HC / NHLBI NIH HHS / United States N01 HC055019 / HC / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States N01 HC085080 / HC / NHLBI NIH HHS / United States R01 HL086694-02 / HL / NHLBI NIH HHS / United States N01 HC055222 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States P30 DK063491-029004 / DK / NIDDK NIH HHS / United States N01 HC055015 / HC / NHLBI NIH HHS / United States N01 HC055021 / HC / NHLBI NIH HHS / United States N01 HC085084 / HC / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States R01 NS017950-23 / NS / NINDS NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States R01 HL093328 / HL / NHLBI NIH HHS / United States P30 DK063491-019004 / DK / NIDDK NIH HHS / United States R01 HL092577-01A1 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R01 HL087641-01 / HL / NHLBI NIH HHS / United States N01 HC055020 / HC / NHLBI NIH HHS / United States P30 DK063491-049004 / DK / NIDDK NIH HHS / United States R01 HL080124 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States R01 AG028321 / AG / NIA NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States R01 HL076784-01 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01 HC055016 / HC / NHLBI NIH HHS / United States M01 RR000425-30S1 / RR / NCRR NIH HHS / United States |