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Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study.
Tuesday,2012-11-06 12:10 America/Los_Angeles — eenright
| Title | Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | O'Connor, GT, Caffo, B, Newman, AB, Quan, SF, Rapoport, DM, Redline, S, Resnick, HE, Samet, J, Shahar, E |
| Journal | Am J Respir Crit Care Med |
| Volume | 179 |
| Issue | 12 |
| Pagination | 1159-64 |
| Date Published | 2009 Jun 15 |
| ISSN | 1535-4970 |
| Keywords | Adult, Blood Pressure, Confidence Intervals, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Hypertension, Incidence, Male, Middle Aged, Odds Ratio, Polysomnography, Prognosis, Prospective Studies, Risk Factors, Sleep Apnea Syndromes, Time Factors, United States |
| Abstract | <p><b>RATIONALE: </b>Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension.</p><p><b>OBJECTIVES: </b>To examine whether sleep-disordered breathing increases the risk of incident hypertension among persons 40 years of age and older.</p><p><b>METHODS: </b>In a prospective cohort study, we analyzed data from 2,470 participants who at baseline did not have hypertension, defined as blood pressure of at least 140/90 mm Hg or taking antihypertensive medication. The apnea-hypopnea index (AHI), the number of apneas plus hypopneas per hour of sleep, was measured by overnight in-home polysomnography. We estimated odds ratios for developing hypertension during 5 years of follow-up according to baseline AHI.</p><p><b>MEASUREMENTS AND MAIN RESULTS: </b>The odds ratios for incident hypertension increased with increasing baseline AHI; however, this relationship was attenuated and not statistically significant after adjustment for baseline body-mass index. Although not statistically significant, the observed association between a baseline AHI greater than 30 and future hypertension (odds ratio, 1.51; 95% confidence interval, 0.93-2.47) does not exclude the possibility of a modest association.</p><p><b>CONCLUSIONS: </b>Among middle-aged and older persons without hypertension, much of the relationship between AHI and risk of incident hypertension was accounted for by obesity. After adjustment for body mass index, the AHI was not a significant predictor of future hypertension, although a modest influence of an AHI greater than 30 on hypertension could not be excluded.</p> |
| DOI | 10.1164/rccm.200712-1809OC |
| Alternate Journal | Am J Respir Crit Care Med |
| PubMed ID | 19264976 |
| PubMed Central ID | PMC2695498 |
| Grant List | U01 HL 53916 / HL / NHLBI NIH HHS / United States U01 HL 53938 / HL / NHLBI NIH HHS / United States U01 HL 53934 / HL / NHLBI NIH HHS / United States U01 HL 53940 / HL / NHLBI NIH HHS / United States U01 HL 53937 / HL / NHLBI NIH HHS / United States U01 HL 63463 / HL / NHLBI NIH HHS / United States U01 HL 53941 / HL / NHLBI NIH HHS / United States U01 HL 64360 / HL / NHLBI NIH HHS / United States U01 HL 63429 / HL / NHLBI NIH HHS / United States U01 HL 53931 / HL / NHLBI NIH HHS / United States |