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Long-term function in an older cohort--the cardiovascular health study all stars study.
Tuesday,2012-11-06 12:10 America/Los_Angeles — eenright
| Title | Long-term function in an older cohort--the cardiovascular health study all stars study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Newman, AB, Arnold, AM, Sachs, MC, Ives, DG, Cushman, M, Strotmeyer, ES, Ding, J, Kritchevsky, SB, Chaves, PHM, Fried, LP, Robbins, J |
| Journal | J Am Geriatr Soc |
| Volume | 57 |
| Issue | 3 |
| Pagination | 432-40 |
| Date Published | 2009 Mar |
| ISSN | 1532-5415 |
| Keywords | Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Attention, Cardiovascular Diseases, Chronic Disease, Cohort Studies, Comorbidity, Cross-Sectional Studies, Female, Follow-Up Studies, Gait, Geriatric Assessment, Hand Strength, Health Surveys, Humans, Male, Memory, Short-Term, Mental Status Schedule, Proportional Hazards Models, Psychometrics, Risk Factors, United States |
| Abstract | <p><b>OBJECTIVES: </b>To evaluate shared and unique risk factors for maintaining physical and cognitive function into the ninth decade and beyond.</p><p><b>DESIGN: </b>Longitudinal cohort study.</p><p><b>SETTING: </b>Four U.S. communities.</p><p><b>PARTICIPANTS: </b>One thousand six hundred seventy-seven participants in the Cardiovascular Health Study All Stars Study, assessed in 2005/06. Median age was 85 (range 77-102), 66.5% were women, and 16.6% were black.</p><p><b>MEASUREMENTS: </b>Intact function was defined as no difficulty with any activities of daily living and a score of 80 or higher on the Modified Mini-Mental State Examination. Baseline characteristics assessed in 1992/93 included demographics, behavioral health factors, chronic disease history, subclinical disease markers, cardiovascular risk factors, and inflammatory markers. Multinomial logistic regression was used to compare risk for physical disability, cognitive impairment,and combined impairments with no functional impairment.</p><p><b>RESULTS: </b>Of the 1,677 participants evaluated in both domains, 891 (53%) were functionally intact. Continuous measures of function, including the Digit Symbol Substitution Test and gait speed, showed that all groups, including the most functional, had declined over time. The functional group had less decline but also tended to have higher starting values. Functional individuals had a higher baseline health profile than those with either or cognitive impairment or both impairments combined. Women and individuals with greater weight had higher rates of physical impairment but not cognitive impairment. Risk factors common to both types of impairment included cardiovascular disease and hypertension.</p><p><b>CONCLUSION: </b>Intact function was found in only approximately half of these older adults in the ninth decade and beyond. High baseline function and low vascular disease risk characterized functional aging.</p> |
| DOI | 10.1111/j.1532-5415.2008.02152.x |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 19187412 |
| PubMed Central ID | PMC2736556 |
| Grant List | R01 HL075366-04 / HL / NHLBI NIH HHS / United States N01 HC085086 / HC / NHLBI NIH HHS / United States P30 AG024827 / AG / NIA NIH HHS / United States R01 AG020098-01 / AG / NIA NIH HHS / United States P30 AG024827-05 / AG / NIA NIH HHS / United States R01 HL075366 / HL / NHLBI NIH HHS / United States R01 AG015928-02 / AG / NIA NIH HHS / United States P30 AG024827-02 / AG / NIA NIH HHS / United States P30 AG024827-01 / AG / NIA NIH HHS / United States N01 HC085081 / HC / NHLBI NIH HHS / United States U01 HL080295-04 / HL / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG023629-03 / AG / NIA NIH HHS / United States N01 HC075150 / HC / NHLBI NIH HHS / United States R01 AG020098-02 / AG / NIA NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC085083 / HC / NHLBI NIH HHS / United States P30-AG-024827 / AG / NIA NIH HHS / United States U01 HL080295-01 / HL / NHLBI NIH HHS / United States HL-075366 / HL / NHLBI NIH HHS / United States R01 AG020098-03 / AG / NIA NIH HHS / United States R01 AG023629-02 / AG / NIA NIH HHS / United States N01 HC085085 / HC / NHLBI NIH HHS / United States R01 AG027058-03 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States U01 HL080295-03 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01 HL075366-05 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States P30 AG024827-019008 / AG / NIA NIH HHS / United States R01 HL075366-03 / HL / NHLBI NIH HHS / United States N01 HC085082 / HC / NHLBI NIH HHS / United States N01 HC085080 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States R01 AG020098-04 / AG / NIA NIH HHS / United States P30 AG024827-03 / AG / NIA NIH HHS / United States R01 AG020098-06A2 / AG / NIA NIH HHS / United States N01 HC055222 / HC / NHLBI NIH HHS / United States R01 HL075366-01A1 / HL / NHLBI NIH HHS / United States R01 AG027058-01 / AG / NIA NIH HHS / United States U01 HL080295-02 / HL / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01-AG-20098 / AG / NIA NIH HHS / United States N01 HC085084 / HC / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States R01 AG023629-01 / AG / NIA NIH HHS / United States R01 HL075366-02 / HL / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States R01-AG-023629 / AG / NIA NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States R01 AG027058-02 / AG / NIA NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States P30 AG024827-04 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States R01-AG-15928 / AG / NIA NIH HHS / United States R01-AG-027058 / AG / NIA NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States P30 AG021332 / AG / NIA NIH HHS / United States R01 AG020098-05 / AG / NIA NIH HHS / United States R01 AG023629-04 / AG / NIA NIH HHS / United States |