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Albuminuria and dementia in the elderly: a community study.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Albuminuria and dementia in the elderly: a community study. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Barzilay, JI, Fitzpatrick, AL, Luchsinger, J, Yasar, S, Bernick, C, Jenny, NS, Kuller, LH |
| Journal | Am J Kidney Dis |
| Volume | 52 |
| Issue | 2 |
| Pagination | 216-26 |
| Date Published | 2008 Aug |
| ISSN | 1523-6838 |
| Keywords | Age Factors, Aged, Aged, 80 and over, Albuminuria, Brain, Cognition, Cross-Sectional Studies, Dementia, Female, Humans, Incidence, Magnetic Resonance Imaging, Male, Odds Ratio, Population Surveillance, Prognosis, Retrospective Studies, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>Dementia is associated with microvascular disease of the retina. In this study, we examine whether cognitive status (normal cognition, mild cognitive impairment, and dementia) is associated with albuminuria, a microvascular disorder of the kidney.</p><p><b>STUDY DESIGN: </b>Cross-sectional analysis.</p><p><b>SETTING & PARTICIPANTS: </b>2,316 participants from the Cardiovascular Health Cognition Study who underwent brain magnetic resonance imaging and testing for albuminuria.</p><p><b>PREDICTOR: </b>Doubling of albuminuria.</p><p><b>OUTCOME: </b>Dementia defined according to neuropsychological and clinical evaluation.</p><p><b>MEASUREMENTS: </b>Multinomial logistic modeling was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of dementia and mild cognitive impairment with doubling of albuminuria compared with the odds with normal cognition.</p><p><b>RESULTS: </b>283 participants (12.2%) had dementia, 344 (14.9%) had mild cognitive impairment, and 1,689 (72.9%) had normal cognition. Compared with participants with normal cognition, doubling of albuminuria was associated with increased odds of dementia (OR, 1.22; 95% CI, 1.15 to 1.29). Adjustment for prevalent cardiovascular disease and cardiovascular risk factors, lipid levels, C-reactive protein level, estimated glomerular filtration rate, and apolipoprotein E-4 genotype attenuated this association, but it remained statistically significant (OR, 1.12; 95% CI, 1.03 to 1.22). Mild cognitive impairment was associated with albuminuria on unadjusted analysis, but not with adjustment for other factors.</p><p><b>LIMITATIONS: </b>Results are cross-sectional; causality cannot be imputed.</p><p><b>CONCLUSIONS: </b>The odds of dementia increased in the presence of albuminuria. These findings suggest a role of shared susceptibility for microvascular disease in the brain and kidney in older adults.</p> |
| DOI | 10.1053/j.ajkd.2007.12.044 |
| Alternate Journal | Am J Kidney Dis |
| PubMed ID | 18468749 |
| PubMed Central ID | PMC2607238 |
| Grant List | N01 HC015103 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |