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Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Reiner, AP, Barber, MJ, Guan, Y, Ridker, PM, Lange, LA, Chasman, DI, Walston, JD, Cooper, GM, Jenny, NS, Rieder, MJ, J Durda, P, Smith, JD, Novembre, J, Tracy, RP, Rotter, JI, Stephens, M, Nickerson, DA, Krauss, RM |
| Journal | Am J Hum Genet |
| Volume | 82 |
| Issue | 5 |
| Pagination | 1193-201 |
| Date Published | 2008 May |
| ISSN | 1537-6605 |
| Keywords | Aged, Bayes Theorem, C-Reactive Protein, Female, Hepatocyte Nuclear Factor 1-alpha, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Polymorphism, Single Nucleotide, Pravastatin, Simvastatin |
| Abstract | <p>Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.</p> |
| DOI | 10.1016/j.ajhg.2008.03.017 |
| Alternate Journal | Am J Hum Genet |
| PubMed ID | 18439552 |
| PubMed Central ID | PMC2427318 |
| Grant List | HC-85083 / HC / NHLBI NIH HHS / United States HC-85082 / HC / NHLBI NIH HHS / United States P30 DK063491-05 / DK / NIDDK NIH HHS / United States U01 HL084689 / HL / NHLBI NIH HHS / United States N01HV48195 / HL / NHLBI NIH HHS / United States N01HG65403 / HG / NHGRI NIH HHS / United States N01-HV-48195 / HV / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U19 AG023122 / AG / NIA NIH HHS / United States HC-85086 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States HC-85084 / HC / NHLBI NIH HHS / United States R01 HL-071862 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States P30 DK063491-039004 / DK / NIDDK NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States HC-85080 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States R01 HL071862 / HL / NHLBI NIH HHS / United States P30 DK063491-029004 / DK / NIDDK NIH HHS / United States U01 HL-069757 / HL / NHLBI NIH HHS / United States P30 DK063491-019004 / DK / NIDDK NIH HHS / United States HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States P30 DK063491-049004 / DK / NIDDK NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States U01 HL069757 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States HC-85085 / HC / NHLBI NIH HHS / United States |