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Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Kaplan, RC, McGinn, AP, Pollak, MN, Kuller, L, Strickler, HD, Rohan, TE, Xue, XN, Kritchevsky, SB, Newman, AB, Psaty, BM |
| Journal | J Am Geriatr Soc |
| Volume | 56 |
| Issue | 4 |
| Pagination | 652-60 |
| Date Published | 2008 Apr |
| ISSN | 1532-5415 |
| Keywords | Activities of Daily Living, Aged, Aged, 80 and over, Biomarkers, Cardiovascular Diseases, Enzyme-Linked Immunosorbent Assay, Fasting, Female, Follow-Up Studies, Hand Strength, Humans, Incidence, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Survival Rate, United States, Walking |
| Abstract | <p><b>OBJECTIVES: </b>To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults.</p><p><b>DESIGN: </b>Cohort study.</p><p><b>SETTING/PARTICIPANTS: </b>One thousand one hundred twenty-two individuals aged 65 and older without prior cardiovascular disease events participating in the Cardiovascular Health Study.</p><p><b>MEASUREMENTS: </b>Baseline fasting plasma levels of IGF-1, IGFBP-1, and IGFBP-3 (defined as tertiles, T1-T3) were examined in relationship to handgrip strength, time to walk 15 feet, development of new difficulties with activities of daily living (ADLs), and mortality.</p><p><b>RESULTS: </b>Higher IGFBP-1 predicted worse handgrip strength (P-trend(T1-T3)<.01) and slower walking speed (P-trend(T1-T3)=.03), lower IGF-1 had a borderline significant association with worse handgrip strength (P-trend(T1-T3)=.06), and better grip strength was observed in the middle IGFBP-3 tertile than in the low or high tertiles (P=.03). Adjusted for age, sex, and race, high IGFBP-1 predicted greater mortality (P-trend(T1-T3)<.001, hazard ratio (HR)(T3vsT1)=1.48, 95% confidence interval (CI)=1.15-1.90); this association was borderline significant after additional confounder adjustment (P-trend(T1-T3)=.05, HR(T3vsT1)=1.35, 95% CI=0.98-1.87). High IGFBP-1 was associated with greater risk of incident ADL difficulties after adjustment for age, sex, race, and other confounders (P-trend(T1-T3)=.04, HR(T3vsT1)=1.40, CI=1.01-1.94). Neither IGF-1 nor IGFBP-3 level predicted mortality or incident ADL difficulties.</p><p><b>CONCLUSION: </b>In adults aged 65 and older, high IGFBP-1 levels were associated with greater risk of mortality and poorer functional ability, whereas IGF-1 and IGFBP-3 had little association with these outcomes.</p> |
| DOI | 10.1111/j.1532-5415.2007.01637.x |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 18312313 |
| PubMed Central ID | PMC: N/A |
| Grant List | 1R01HL083760-01 / HL / NHLBI NIH HHS / United States N01 HC-15103 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States |