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Cystatin C and aging success.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Cystatin C and aging success. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Sarnak, MJ, Katz, R, Fried, LF, Siscovick, D, Kestenbaum, B, Seliger, S, Rifkin, D, Tracy, R, Newman, AB, Shlipak, MG |
| Corporate/Institutional Authors | Cardiovascular Health Study, |
| Journal | Arch Intern Med |
| Volume | 168 |
| Issue | 2 |
| Pagination | 147-53 |
| Date Published | 2008 Jan 28 |
| ISSN | 0003-9926 |
| Keywords | Aged, Aging, Biomarkers, Creatinine, Cystatin C, Cystatins, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney, Male |
| Abstract | <p><b>BACKGROUND: </b>To our knowledge, the effect of kidney function on successful aging has not been examined.</p><p><b>METHODS: </b>We evaluated the relationship between cystatin C and aging success during a 6-year follow-up in the Cardiovascular Health Study, a community-based cohort of older adults (aged >or= 65 years). Successful aging was defined as remaining free of cardiovascular disease, cancer, and chronic obstructive pulmonary disease and having intact physical and cognitive functioning. In adjusted analysis, an accelerated failure time model was used to evaluate the percentage reduction in successful years by level of cystatin C. A separate Cox proportional hazards model evaluated whether cystatin C was related to incident physical and cognitive disability.</p><p><b>RESULTS: </b>A total of 2140 participants had cystatin C measured and were free of the previously mentioned conditions at baseline. Their mean age was 74 years. The mean cystatin C level, creatinine level, and estimated glomerular filtration rate were 1.06 mg/L, 0.93 mg/dL, and 78 mL/min/1.73 m(2), respectively (to convert cystatin C to nanomoles per liter, multiply by 75; and to convert creatinine to micromoles per liter, multiply by 88.4). A total of 873 participants reached a first event in follow-up, 138 because of cognitive disability, 238 because of physical disability, 34 because of chronic obstructive pulmonary disease, 146 because of cancer, and 317 because of cardiovascular disease. The adjusted percentage reduction in successful life years in the highest vs the lowest quartile of cystatin C was 27% (95% confidence interval, 11%-39%). The highest vs lowest quartile of cystatin C also was independently associated with incident cognitive or physical disability (hazard ratio, 1.39; 95% confidence interval, 1.00-1.98).</p><p><b>CONCLUSION: </b>A higher cystatin C level, even within a range of relatively normal kidney function, was associated with unsuccessful aging.</p> |
| DOI | 10.1001/archinternmed.2007.40 |
| Alternate Journal | Arch Intern Med |
| PubMed ID | 18227360 |
| PubMed Central ID | PMC2871318 |
| Grant List | R01AG027002 / AG / NIA NIH HHS / United States R01 AG027002-01 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01 AG027002 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States |