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Fasting and Postload Nonesterified Fatty Acids and Glucose Dysregulation in Older Adults.
Tuesday,2023-03-07 09:54 America/Los_Angeles — ecterry
| Title | Fasting and Postload Nonesterified Fatty Acids and Glucose Dysregulation in Older Adults. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Shitole, SG, Biggs, ML, Ix, JH, Fretts, AM, Tracy, RP, Siscovick, DS, Djoussé, L, Mukamal, KJ, Kizer, JR |
| Journal | Am J Epidemiol |
| Volume | 191 |
| Issue | 7 |
| Pagination | 1235-1247 |
| Date Published | 2022 Jun 27 |
| ISSN | 1476-6256 |
| Keywords | Aged, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Fatty Acids, Nonesterified, Female, Glucose, Humans, Insulin, Insulin Resistance, Male, Prospective Studies |
| Abstract | <p>To evaluate the association of nonesterified fatty acids (NEFA) with dysglycemia in older adults, NEFA levels were measured among participants in the Cardiovascular Health Study (United States; enrolled 1989-1993). Associations with insulin sensitivity and pancreatic β-cell function, and with incident type 2 diabetes mellitus (DM), were examined. The sample comprised 2,144 participants (aged 77.9 (standard deviation, 4.5) years). Participant data from the Cardiovascular Health Study visit in 1996-1997 was used with prospective follow-up through 2010. Fasting and postload NEFA showed significant associations with lower insulin sensitivity and pancreatic β-cell function, individually and on concurrent adjustment. Over median follow-up of 9.7 years, 236 cases of DM occurred. Postload NEFA were associated with risk of DM (per standard deviation, hazard ratio = 1.18, 95% confidence interval: 1.08, 1.29), but fasting NEFA were not (hazard ratio = 1.12, 95% confidence interval: 0.97, 1.29). The association for postload NEFA persisted after adjustment for putative intermediates, and after adjustment for fasting NEFA. Sex and body mass index modified these associations, which were stronger for fasting NEFA with DM in men but were accentuated for postload NEFA in women and among leaner individuals. Fasting and postload NEFA were related to lower insulin sensitivity and pancreatic β-cell function, but only postload NEFA were associated with increased DM. Additional study into NEFA metabolism could uncover novel potential targets for diabetes prevention in elders.</p> |
| DOI | 10.1093/aje/kwac044 |
| Alternate Journal | Am J Epidemiol |
| PubMed ID | 35247051 |
| Grant List | N01HC85080 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States K24 HL135413 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG053325 / AG / NIA NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States |
ePub date:
22/03