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Competing risk of mortality in association studies of non-fatal events.
Monday,2021-08-23 16:10 America/Los_Angeles — ecterry
| Title | Competing risk of mortality in association studies of non-fatal events. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Bůzková, P |
| Journal | PLoS One |
| Volume | 16 |
| Issue | 8 |
| Pagination | e0255313 |
| Date Published | 2021 |
| ISSN | 1932-6203 |
| Abstract | <p>In geriatric research of non-fatal events, participants often die during the study follow-up without having the non-fatal event of interest. Cause-specific (CS) hazard regression and Fine-Gray (FG) subdistribution hazard regression are the two most common estimation approaches addressing such competing risk. We explain how the conventional CS approach and the FG approach differ and why many FG estimates of associations are counter-intuitive. Additionally, we clarify the indirect link between models for hazard and models for cumulative incidence. The methodologies are contrasted on data from the Cardiovascular Health Study, a population-based study in adults aged 65 years and older.</p> |
| DOI | 10.1371/journal.pone.0255313 |
| Alternate Journal | PLoS One |
| PubMed ID | 34388170 |
| PubMed Central ID | PMC8362942 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |
ePub date:
21/08